Lane restrictions are expected to take place on the Parkway East inbound early Saturday.
PennDOT officials said a single-lane restriction is planned for 6 a.m. to noon in Pittsburgh.
The restriction is for bridge inspection on the Greenfield Bridge between the Squirrel Hill/Homestead (Exit 74) and Oakland (Exit 73B) interchanges.
Crews from The Larson Design Group will conduct the inspection.
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